Publications

After joining Syracuse University

Bold: ACompChemLab members. | * Corresponding authors

33

S. Maity, R. Sarangi, and A. Acharya*

Effects of conformational sampling on redox properties

To be communicated.

32

Md. S. Hossain, Z. Huang, F. Mousazadeh, R. Sarangi, E. de Jong, K. C. Kolamunna, Z. Zhang, A. Adhya, J. L. Hougland, A. Acharya, D. Mozhdehi

Scalable One-Pot Production of Geranylgeranylated Proteins in Engineered Prokaryotes

Submitted

31

D. Britton, M.-W. Kim, C. Liu, S. Maity, S. Jia, A. Acharya, S. S. Lee, and J. K. Montclare 

Protein-engineered photoresponsive conductive nanofibers 

Submitted

30

S. C. Mandal, R. Sarangi, and A. Acharya*

Impact of native environment and protein-protein interactions in multiheme-cytochrome chains

Submitted

29

X. Fu, B. Xu, S. Maity, M. Wu, L. G. Westbrook, K. Edwards, A. Acharya*, and X. Hu* 

Bioorthogonal Regulation of Self-Immolation and Controlled Release Using Cucurbit[7]uril Supramolecular Chemistry


Submitted; ChemRxiv Link.

28

R. Sarangi, S. Maity, and A. Acharya*

Machine Learning Approach To Vertical Energy Gap in Redox Processes

J. Chem. Theory Comput. 2024, 20, 15, 6747–6755


Download the code

27

D. Sil, E. Osmanbasic, S. C. Mandal, A. Acharya, and C. Dutta

Variable Non-Gaussian Transport of Nanoplastic on Supported Lipid Bilayers in Saline Conditions.

J. Phys. Chem. Lett. 2024, 15, 5428-5435

26

S. Maity and A. Acharya*

Many roles of carbohydrates: A computational spotlight on the coronavirus S protein binding.

ACS Appl. Bio Mat. 2024, 7, 646-656

25

V. G. Lui, M. Hoenig, B. Cabrera-Martinez, R. M. Baxter, J. E. Garcia-Perez, A. Acharya, K. Lundquist, J. Capera, P. Matusewicz, F. A. Hartl, M. D’Abramo, J. Alba, E.-M. Jacobsen, D. Niewolik, M. Lorenz, U. Pannicke, A. S.  Schulz, K.-M. Debatin, W. W. Schamel, S. Minguet, J. C. Gumbart, M. L. Dustin, J. C. Cambier, K. Schwarz, E. W.Y. Hsieh

A partial human LCK defect causes a T cell immunodeficiency with intestinal 2 inflammation. 

J. Exp. Med. 2024, 221, e20230927.

24

S. Sarkar*, A. Shil, S. Maity, Y. L. Jung, M. Dai, A. Acharya*, and K. H. Ahn*

A General Strategy Toward pH-Resistant Phenolic Fluorophores for High-Fidelity Sensing and Bioimaging Application. 

Angew. Chem. Int. Ed. 2023, 62, e202311168. 

23

Y. Li, A. Acharya, L. Yang, J. Liu, E. Tajkhorshid, H. I. Zgurskaya, M. Jackson, and J. C. Gumbart

Insights into substrate transport and water permeation in the mycobacterial transporter MmpL3.

Biophys. J. 2023, 122, 2342-2352


Data repository

22

Y. T. Pang, A. Acharya, D. L. Lynch, A. Pavlova, J. C. Gumbart; first authorship shared

SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

Commun. Biol. 2022, 5, 1170

Press: Phys.org, SU News, and A&S News

Before joining Syracuse University

21. C. Stevens, S. Babii, A. N. Pandya, W. Li, Y. Li, J. Mehla, R. Scott, P. Hegde, P. K. Prathipati, A. Acharya, J. Liu, J. C. Gumbart, J. North, M. Jackson, and H. I. Zgurskaya. 

Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors.

Proc. Nat. Acad. Sci. USA. 2022, 119, e2113963119

Press: Phys.org, ThePrint, Hindustan Times, and Times Now

20. B. Yu, M. R. Choudhury, X. Yang, S. L. Benoit, E. Womack, K. V. M. Lyles, A. Acharya, A. Kumar, C. Yang, A. Pavlova, M. Zhu, Z. Yuan, J. C. Gumbart, D. W. Boykin, R. J. Maier, Z. Eichenbaum, and B. Wang

Restoring and enhancing the potency of existing antibiotics against drug-resistant Gram-negative bacteria through the development of potent small-molecule adjuvants.

ACS Infect. Dis. 2022, 8, 1491-1508 

19. P. J. Dahl, S. M. Yi, Y. Gu, A. Acharya, C. Shipps, J. Neu, J. P. O’Brien,  U. N. Morzan, S. Chaudhuri, M. J. Guberman-Pfeffer, D. Vu, S. E. Yalcin, V. S. Batista, and N. S. Malvankar

A 300-fold conductivity increase in microbial cytochrome nanowires due to temperature-induced restructuring of hydrogen bonding networks. 

Sci. Adv. 2022, 8, eabm7193

Press: ErekAlert, Phys.org, SciTechDaily, ChemEurope, Bioengineer, and Yale News

18. A. Acharya, D. Yi, A. Pavlova, V.A. Agarwal, and J. C. Gumbart

Resolving the hydride transfer pathway in oxidative conversion of proline to pyrrole

Biochemistry 2021, 61, 206-215

17. A. Acharya*, D. L. Lynch, A. Pavlova, Y. T. Pang, and J. C. Gumbart; *co-corresponding author.

ACE2 glycans preferentially interact with SARS-CoV-2 over SARS-CoV. 

Chem. Commun. 2021, 57, 5949-5952

16. A. Pavlova, Z. Zhang, A. Acharya, D. L. Lynch, Y. T. Pang, Z. Mou, J. M. Parks, C. Chipot, and J. C. Gumbart; 

Machine learning reveals the critical interactions for SARS-CoV-2 spike protein binding to ACE2 

J. Phys. Chem. Lett. 2021, 12, 5494-5502

15. D. Yi, A. Acharya, J. C. Gumbart, W. Gutekunst, and V. Agarwal

Gatekeeping ketosynthases dictate initiation of assembly line biosynthesis of pyrrolic polyketides. 

J. Am. Chem. Soc. 2021, 143, 7617-7622

14. Z. Zhang, D. Ryoo, C. Balusek, A. Acharya, M. O. Rydmark, D. Linke, And J. C. Gumbart

Resolving the relationships between sequence, shape, and size of β-barrel membrane proteins. 

BBA – Biomembranes 2021, 1863, 183662

13. A. Pavlova, D. L. Lynch, I. Daidone, L. Zanetti-Polzi, M. D. Smith, C. Chipot, D. W. Kneller, A. Kovalevsky, L. Coates, A. A. Golosov, C. J. Dickson, C. Velez-Vega, J. S. Duca, J. V. Vermaas, Y. T. Pang, A. Acharya, J. M. Parks, J. C. Smith, and J. C. Gumbart.

Inhibitor binding influences the protonation states of histidines in SARS-CoV-2 main protease. 

Chem. Sci. 2021, 12, 1513-1527

12. A. Acharya, R. Agarwal, M. B. Baker, J. Baudry, D. Bhowmik, S. Boehm, K. G. Byler, S. Y. Chen, L. Coates, C. J. Cooper, O. Demerdash, I. Daidone, J. D. Eblen, S. Ellingson, S. Forli, J. Glaser, J. C. Gumbart, J. Gunnels, O. Hernandez, S. Irle, D. W. Kneller, A. Kovalevsky, J. Larkin, T. J. Lawrence, S. LeGrand, S.-H. Liu, J.C. Mitchell, G. Park, J.M. Parks, A. Pavlova, L. Petridis, D. Poole, L. Pouchard, A. Ramanathan, D. M. Rogers, D. Santos-Martins, A. Scheinberg, A. Sedova, Y. Shen, J. C. Smith*, M. D. Smith, C. Soto, A. Tsaris, M. Thavappiragasam, A. F. Tillack, J. V. Vermaas, V. Q. Vuong, J. Yin, S. Yoo, M. Zahran, and L. Zanetti-Polzi 

Supercomputer-based ensemble docking drug discovery pipeline with application to Covid-19. 

J. Chem. Inf. Model. 2020, 60, 5832–5852

Press: ScienMag, Bioengineer.org, Phys.org, EurekAlert, and Observer.    

11. S. E. Yalcin, J. P. O’Brien, Y. Gu, K. Reiss, S. M. Yi, R. Jain, V. Srikanth, P. Dahl, W. Huynh, D. Vu, A. Acharya, S. Chaudhuri, T. Varga, V. S. Batista, and N. S. Malvankar

Electric field stimulates production of highly conductive microbial OmcZ nanowires

Nat. Chem. Biol. 2020, 16, 1136-1142


News and Views, Press: Yale press release, Scientific American, Phys.org, ErekAlert, Live Science, Oxford Instruments, NBC-SYFY, American Society of Microbiology (podcast @16:30), greenreport (italy), SciTechDaily, and SpaceDaily. In 98th percentile across all journals.

10. A. Acharya, J. Stockmann, L. Beyer, A. Nabers, J. C. Gumbart, K. Gerwert, and V. S. Batista

The effect of (-)-epigallocatechin-3-gallate on the amyloid-ß secondary structure

Biophys. J. 2020, 119, 349-359

9. K. W. East, J. C. Newton, U. N. Morzan, Y. Narkhede, A. Acharya, E. Skeens, G. Jogl, V. S. Batista, G. Palermo, G. P. Lisi

Allosteric motions of the CRISPR-Cas9 HNH nuclease probed by NMR and molecular dynamics. 

J. Am. Chem. Soc., 2020, 142, 1348-1358

8. T. Sen, A. V. Mamontova, A. V. Titelmayer, A. M. Shakhov, A. A. Astafiev, A. Acharya, K. A. Lukyanov, A. I. Krylov, and A. M. Bogdanov

Influence of the first chromophore-forming residue on photobleaching and oxidative photoconversion of EGFP and EYFP. 

Int. J. Mol. Sci., 2019, 20, 5229

7. S. Chaudhuri, A. Acharya, E. T. J. Nibbering, and V. S. Batista

Regioselective ultrafast photoinduced electron transfer from naphthols to halocarbon solvents

J. Phys. Chem. Lett., 2019, 10, 2657–2662

6. J. A. Christensen, B. T. Phelan, S. Chaudhuri, A. Acharya, V. S. Batista, and M. R. Wasielewski 

Phenothiazine radical cation excited states as super-oxidants for energy-demanding reactions. 

J. Am. Chem. Soc., 2018, 140, 5290-5299

5. A. Acharya*, S. Chaudhuri, and V. S. Batista; * co-corresponding author.

Can TDDFT describe excited electronic states of naphthol photoacids? A closer look with EOM-CCSD. 

J. Chem. Theory Comput. 2018, 14, 867-876

4. A. Acharya, A. M. Bogdanov, B. L. Grigorenko, K. B. Bravaya, A. V. Nemukhin, K. A. Lukyanov, and A. I. Krylov

Photoinduced chemistry in fluorescent proteins: Curse or blessing? 

Chem. Rev., 2017, 117, 758 – 795

3. P. K. Gurunathan, A. Acharya, D. Ghosh, D. Kosenkov, I. Kaliman, Y. Shao, A. I. Krylov, and L. V. Slipchenko; first authorship shared.

The extension of the effective fragment potential method to macromolecule. 

J. Phys. Chem. B, 2016, 120, 6562 – 6574

2. A. M. Bogdanov, A. Acharya, A. Titelmayer, A. V. Mamontova, K. B. Bravaya, A. B. Kolomeisky, K. A. Lukyanov, and A. I. Krylov; first authorship shared.

Turning on and off photoinduced electron transfer in fluorescent proteins by pi-stacking, halide binding, and Tyr145 mutations. 

J. Am. Chem. Soc., 2016, 138, 4807 – 4817. ACS Live Slide 

1. D. Ghosh, A. Acharya, S.C. Tiwari, and A.I. Krylov 

Towards understanding the redox properties of model chromophores from the green fluorescent protein family: An interplay between conjugation, resonance stabilization, and solvent effects. 

J. Phys. Chem. B, 2012, 116, 12398 – 12405

PERSPECTIVE

1.B. Rudshteyn, A. Acharya, and V. S. Batista

Is the supporting information the venue for reproducibility and transparency? 

J. Phys. Chem. A 2017, 121, 968. Link To Article

J. Phys. Chem. B 2017, 121, 11425. Link To Article

J. Phys. Chem. C 2017, 121, 28212. Link To Article

Published Articles/Reviews